主讲人:庄志豪教授
时间:6月13日上午10:00
地点:深圳大学丽湖校区守信楼(原B1栋)420会议室
报告人简介:
庄志豪于1997年在四川大学获得学士学位,随后在新墨西哥大学(博士学位)和宾夕法尼亚州立大学(博士后)继续深造, 2007年在特拉华大学(University of Delaware)化学与生物化学系担任助理教授,2013年晋升副教授(Tenured),2019年晋升终身教授。在化学和生物学的交叉领域探索泛素在蛋白质翻译后修饰、去泛素化、蛋白质降解的功能,并发展了蛋白质泛素化的化学方法,和针对去泛素化酶(DUB)的蛋白质探针和小分子抑制剂,以及新型小分子诱导蛋白质降解技术,在这些领域取得一系列创新性的研究成果。截止目前,已在Nature Chemical biology, J. Am. Chem. Soc., PNAS, Chemical Science, ACS Chemical Biology 等学术期刊发表论文近六十篇,获得包括美国国家科学基金会CAREER和美国癌症协会Research Scholar的多个奖项,也曾担任美国国立卫生研究院和美国国家科学基金会评审委员。
讲座摘要:
Posttranslational modification of proteins by ubiquitin (Ub) is a crucial regulatory mechanism in various cellular processes. Ubiquitin-mediated pathways are being rapidly discovered in different aspects of cell biology. Human deubiquitinases (DUBs) are an emerging class of therapeutic targets for drug discovery against cancer and neurodegenerative diseases. Activity-based DUB probes are powerful tools for identifying new DUB functions, understanding DUB catalysis and specificity, and developing DUB inhibitors. My lab has developed protein- and polyubiquitin-based DUB probes that helped identify DUBs targeting specific proteins, and elucidate the mode of ubiquitin chain recognition and cleavage by human ubiquitin-specific protease (USP). We have also worked on cell-permeable DUB probes that enable DUB profiling in live cells and inhibitor discovery. These chemical biology approaches offer insights into various cellular processes that involve protein ubiquitination and deubiquitination, laying the groundwork for future development of therapeutics that modulate DUBs.
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