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高春梅

    职务:教师 
    职称:副教授 
    办公电话:0755-26926643 
    Email:gaocm@szu.edu.cn

教师简介

一、简历

u 2017.6-至今,深圳大学化学与环境工程学院,副教授

u 2009.3-2017.5,清华大学深圳研究生院,讲师,副教授

u 2007.3-2009.3,清华大学,博士后

u 2001.9-2006.12中国科学院广州化学研究所,博士

u 1997.9-2001.7徐州师范大学,学士

二、研究方向

研究方向:有机小分子或聚合物的设计、合成及应用

1. 热电材料领域

探索和开发新型可再生清洁能源和高效能量转换与存储技术,具有重要的理论意义和市场应用前景。将热电材料用于工业废热回收、汽车尾气余热回收来进行发电,或用于制备空调系统,不仅可提高燃油的利用率,还可降低废气的排放,保护环境。本课题组致力于小分子或高分子聚合物热电材料的研究,探讨化合物结构对热电性能的影响,研发性能优异的热电材料。

2. 肿瘤治疗领域  

肿瘤疾病严重威胁人类的生命健康,本课题组针对肿瘤的信号传导网络,设计研发新的药物先导化合物,研究其抗肿瘤活性及其作用机制。

 

三、 科研项目
近年来主持科研项目如下:

1. 吖啶/碳纳米管复合热电材料的制备及性能研究深圳市基础研究计划 2019-202050万元

2. 基于系统药理学和高通量筛选技术的多靶点抗肿瘤药物研发,863子课题,2012-20152012AA02030592.5万元

3. 基于靶点拓扑异构酶和PARP1的吖啶类化合物的合成与抗肿瘤活性研究,国家自然科学基金面上项目,2014-201780万元

4. 端粒酶抑制剂:特异性识别肿瘤细胞的吖啶酮类化合物的合成及活性研究,国家自然科学基金青年基金,2010-20122090205319万元

5. 新型磷酰化苯并内酰胺药物的合成和生物活性研究,中国博士后科学基金,2007-20093万元

6. 20150266:新靶点及多靶点组合抗肿瘤药物技术研发,深圳市技术开发,2015-2017200万元

7. DNA甲基转移酶与组蛋白去乙酰化酶为靶点的化合物的设计、合成与活性研究,深圳市基础研究计划,2015-2017 30万元

四、 论文发表

1.       Chunmei Gao, Yijia Liu, Yuan Gao, * Yan Zhou,Xiaoyan Zhou, Xiaojun Yin, Chengjun Pan, Chuluo Yang, Hanfu Wang, GuangmingChen, * and Lei Wang*, High-performance n-type thermoelectric composites ofacridones with tethered tertiary amines and carbon nanotubes, Journal of MaterialsChemistry A, minorrevision IF: 9.931(JCR1)

2.       XiaojunYin, Yuhao Peng, Jiajia Luo, Xiaoyan Zhoum, Chunmei Gao*, Lei Wang*,Chuluo Yang*, Tailoringthe framework of organic small molecule semiconductors towards high-performancethermoelectric composites viaconglutinated carbon nanotube webs, Journal of Materials Chemistry A,2018, 6, 8323-8330. IF: 9.931(JCR1)

3.       LuhaiWang, Chengjun Pan*, Zhongming Chen, Xiaoyan Zhou, Chunmei Gao* and LeiWang*, A study of the thermoelectric properties ofbenzo[1,2-b:4,5-b′]dithiophene–based donoracceptor conjugated polymers, PolymerChemistry, 2018, DOI: 10.1039/C8PY00812D. IF: 4.927 (JCR1)

4.       XiaoyanZhou, Chengjun Pan, Ansheng, Liang, Luhai, Wang, Tao Wan, Guanghui Yang, ChunmeiGao* and Wai-Yeung Wong, Enhanced figure of merit ofpoly(9,9-di-n-octylfluorene-altbenzothiadiazole) and SWCNT thermoelectriccomposites by doping with FeCl3, Journal of Applied PolymerScience, 2018, DOI: 10.1002/APP.47011 IF: 1.901 (JCR3)

5.       BinZhang, Ning Wang, Cunlong Zhang, Chunmei Gao*, Wei Zhang,Kang Chen, Yuyang Jiang*, European Journal of Medicinal Chemistry.2017, 129, 337-348. IF: 4.816 (JCR2)

6.       DanLi, Zigao Yuan, Shaopeng Chen, Cunlong Zhang, Lu Song, Chunmei Gao*, Yuzong Chen, ChunyanTan, and Yuyang Jiang*. Bioorganic & Medicinal Chemistry, 2017, 25,3437-3446. IF: 2.881 (JCR3)

7.       Zigao Yuan, Qinsheng Sun, Dan Li,Shuangshuang Miao, Shaopeng Chen, Lu Song, Chunmei Gao*,Yuzong Chen, Chunyan Tan, Yuyang Jiang*, Design, synthesisand anticancer potential of NSC-319745 hydroxamic acid derivatives as DNMT andHDAC inhibitors. European Journal of Medicinal Chemistry, 2017,134,281-92. IF: 4.816 (JCR2)

8.       Zigao Yuan, Shaopeng Chen, Qinsheng Sun,Ning Wang, Dan Li, Shuangshuang Miao, Chunmei Gao*, YuzongChen, Chunyan Tan, Yuyang Jiang*, Olaparib hydroxamic acidderivatives as dual PARP and HDAC inhibitors for cancer therapy. Bioorganic& Medicinal Chemistry, 2017, 25, 4100-4109. IF: 2.881 (JCR3)

9.       Zigao Yuan, Jiwei Chen, Wenlu Li, DanLi, Changjun Chen, Chunmei Gao*, Yuyang Jiang*,PARP inhibitors as antitumor agents: a patent update (2013-2015). ExpertOpinion on Therapeutic Patents, 2017, 27, 363-382. IF: 4.598(JCR2)

10.    Zigao Yuan, Shaopeng Chen,Changjun Chen, Jiwei Chen, Chengken Chen, Qiuzi Dai, Chunmei Gao*,and Yuyang Jiang*, European Journal of Medicinal Chemistry,2017,138,1135-1146.IF: 4.816 (JCR2)

11.    ZhishanCui, Shaopeng Chen, YanweiWang, Chunmei Gao*, Yuzong Chen,Chunyan Tan, Yuyang Jiang*, Design, synthesis and evaluationof azaacridine derivatives as dual-target EGFR and Src kinase inhibitors forantitumor treatment. European Journal of Medicinal Chemistry, 2017, 136,372-381. IF: 4.816 (JCR2)

12.    WeiZhang, Bin Zhang, Wei Zhang, Ti Yang, Ning Wang, Chunmei Gao*, ChunyanTan, Hongxia Liu, Yuyang Jiang*. Synthesis and antiproliferative activity of9-benzylamino-6-chloro-2-methoxy-acridine derivatives as potent DNA-bindingligands and topoisomerase II inhibitors. European Journal of MedicinalChemistry, 2016,116, 59-70. IF: 4.816 (JCR2)

13.    HuixiongXie, Dan Tao, Jiangpeng Ni, Xiongzhi Xiang, Chunmei Gao*, Lei Wang*.Synthesis and properties of highly branched star-shaped sulfonated blockpolymers with sulfoalkyl pendant groups for use as proton exchange membranes. Journalof Membrane Science,2016, 497, 55-66. IF: 6.578 (JCR1)

14.    WenluLi, Xi Li, Bin Zhang, Chunmei Gao*, Yuzong Chen, Yuyang Jiang*. Currentprogresses and trends in the development of progesterone receptor modulators. CurrentMedicinal Chemistry, 2016,23, 2507-2554. IF: 3.469 (JCR2)

15.    ZhishanCui, Xi Li, Lulu Li, Bin Zhang*, Chunmei Gao*, Yuzong Chen, Chunyan Tan,Hongxia Liu, Weiyi Xie, Ti Yang, & Yuyang Jiang. Design, synthesis andevaluation of acridine derivatives as multi-target Src and MEK kinaseinhibitors for anti-tumor treatment. Bioorganic & Medicinal Chemistry,2016,24, 261-269. IF: 2.881 (JCR3)

16.    ChangjunChen, HaiyangLiu, Bin Zhang, Yanwei Wang, Kai Cai, Ying Tan*, Chunmei Gao*,Hongxia Liu, Chunyan Tan, Yuyang Jiang. A simple benzimidazolequinoline-conjugate fluorescent chemosensor for highly selective detection ofAg+. Tetrahedron, 2016,72, 3980-3985. IF:2.377 (JCR3)

17.    Chunmei Gao*, WeiZhang, Shengnan He, Shangfu Li, Feng Liu*, Yuyang Jiang. BioorganicChemistry, 2015, 60, 30-36. IF: 3.929 (JCR3)

18.    Bin Zhang, Kang Chen, NingWang, Chunmei Gao*, Qinsheng Sun, Lulu Li, Yuzong Chen, Chunyan Tan,Hongxia Liu, Yuyang Jiang*, Molecular design, synthesis and biologicalresearch of novel pyridyl acridones as potent DNA-binding and apoptosis-inducingagents. European journal of medicinal chemistry, 2015, 93, 214-26. IF:4.816 (JCR2)

19.    Xi Li, Chunmei Gao*,Ti Yang, Bin Zhang, Chunyan Tan, Hongxia Liu, Yuyang Jiang*, APOCl3-mediated synthesis of substituted fused azoacridones derivatives. RscAdvances, 2015, 5, 28670-8. IF: 2.936 (JCR3)

20.    Chunmei Gao*, Bin Li, Bin Zhang,Qinsheng Sun, Lulu Li, Xi Li, Changjun Chen, Hongxia Liu, Yuyang Jiang*,Synthesis and biological evaluation of benzimidazole acridine derivatives aspotential DNA-binding and apoptosis-inducing agents. Bioorganic &Medicinal Chemistry, 2015, 23, 1800-1807. IF: 2.881 (JCR3)

21.    Hongbo Chen, Xiaobin Zeng,Chunmei Gao(并列一作), Pinghong Ming, Jianping Zhang, Caiping Guo, Lanzhen Zhou, Yin Lu,Lijun Wang, Laiqiang Huang, Xiangjiu He, Lin Mei, A new arylbenzofuranderivative functions as an anti-tumour agent by inducing DNA damage andinhibiting PARP activity. Scientific Reports, 2015, 5, 10893. IF: 4.122(JCR3)

22.    Bin Zhang, Xi Li, Bin Li, ChunmeiGao*, Yuyang Jiang*,Acridine and its derivatives: a patentreview (2009-2013). Expert opinion on therapeutic patents, 2014, 24,647-664. IF: 4.598(JCR2)

23.    Bin Li, Chunmei Gao*,Qinsheng Sun, Lulu Li, Chunyan Tan, Hongxia Liu, Yuyang Jiang*, Novelsynthetic acridine-based derivatives as topoisomerase I inhibitors. ChineseChemical Letters, 2014, 25, 1021-1024. IF: 2.631(JCR4)

24.    Xuliang Lang, QinshengSun, Yuzong Chen, Lulu Li, Chunyan Tan, Hongxia Liu, Yuyang Jiang*,Novel synthetic 9-benzyloxyacridine analogue as both tyrosine kinase andtopoisomerase I inhibitor. Chinese Chemical Letters,2013, 24,677-680. IF: 2.631(JCR4)

25.    Xuliang Lang, Lulu Li,Yuzong Chen, Qinsheng Sun, Qin Wu, Feng Liu, Chunyan Tan, Hongxia Liu, ChunmeiGao*, Yuyang Jiang*, Novel synthetic acridine derivatives as potentDNA-binding and apoptosis-inducing antitumor agents. Bioorganic &Medicinal Chemistry, 2013, 21:4170-7 IF: 2.881 (JCR3)

26.    Jinshun Lin, Xiuli Jin,Yiwen Bu, Deliang Cao, Nannan Zhang, Shangfu Li, Qinsheng Sun, Chunyan Tan, ChunmeiGao*, Yuyang Jiang*, Efficient synthesis of RITA and its analogues:derivation of analogues with improved antiproliferative activity via modulationof p53/miR-34a pathway. Organic & Biomolecular Chemistry, 2012, 10,9734-46. IF: 3.423 (JCR2)

27.    Chunmei Gao*, Shangfu. Li,Xuliang Lang, Hongxia Liu, Feng Liu, Chunyan Tan, & Yuyang Jiang*, 2012, Tetrahedron,68, 7920-7925. IF: 2.377 (JCR3)

28.    Xuliang Lang, Xudong Luan,Chunmei Gao*, Yuyang Jiang*, Recent Progress of Acridine Derivativeswith Antitumor Activity, Progress in Chemistry 2012, 24, 1497-505. IF: 0.82(JCR4)

29.   LeiWang, Guangming Zhu, Junqin Li, Chunmei Gao*, Synthesis andcharacterization of partially fluorinated poly(fluorenyl ether ketone)s withdifferent degrees of sulfonation as proton exchange membranes, PolymerBulletin2011, 66(7), 925-937. IF: 1.589 (JCR4)

30.   ChunmeiGao, FengLiu, Xudong Luan, Chunyan Tan, Hongxia Liu, Yonghua Xie, Yibao Jin, YuyangJiang*, Novel synthetic2-amino-10-(3,5-dimethoxy)benzyl-9(10H)-acridinone derivatives as potentDNA-binding antiproliferative agents. Bioorganic & Medicinal Chemistry,2010, 18, 7507-7514. IF: 2.881 (JCR3)

31.   ChunmeiGao,Yuyang Jiang*, Chunyan Tan, Xuyu Zu, Huacheng Liu, Derong Cao, Synthesisand potent antileukemic activities of 10-benzyl-9(10H)-acridinones. Bioorganic& Medicinal Chemistry, 2008, 16, 8670-8675. IF: 2.881 (JCR3)

32.   ChunmeiGao,Huacheng Liu, Yuyang Jiang*, Chunyan Tan, Derong Cao, Synthesis of10-Benzyl-9-acridone and Its Reduction with NaBH4. Chinese Journal ofOrganic Chemistry, 2008, 28,1803-1806. IF: 1.392 (JCR4)

33.   ChunmeiGao,Derong Cao*, Sheyang Xu, Herbert Meier, Acid-catalyzed cyclization ofanthracenol derivatives to homotriptycenes. Journal of Organic Chemistry,2006, 71, 3071-3076. IF: 4.805 (JCR2)

34.   ChunmeiGao,Derong Cao, Sheyang Xu. Acid-catalyzed selective cyclization of10,10-dibenzyl-9(10H)-anthranol. Acta Chim Sinica, 2006, 64, 1757-60. IF: 2.735 (JCR4)

 

 

五、对学生基本要求
勤奋、认真、踏实,责任心强。