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刘翼振，男，武汉大学分析化学博士，副教授(独立PI)，博士生导师，深圳市高层次人才，深圳大学优秀硕士生导师，中国化学会会员。现任深圳大学发展规划部副主任、化学与环境工程学院院长助理。
课题组依托深圳市纳米生物传感技术重点实验室、深圳大学纳米传感与分子诊疗研究中心开展CRISPR分子诊断前沿技术研究，课题组具备充足的硬件条件（独立办公位、qPCR、多功能酶标仪、分区PCR实验室等）和良好的学习工作氛围。
研究方向：
课题组围绕重大疾病精准诊断领域的需求开展方法学研究，已在本领域具备良好的梯队传承、在国内外具备学术影响力。2025年6月，课题组独立完成的有关CRISPR/Cas分子诊断技术的研究成果发表在国际顶尖学术期刊《Nature Biomedical Engineering》上。近三年，课题组主要研究成果均发表在Analytical Chemistry、Biosensors and Bioelectronics等分析化学领域著名顶刊上。
1 核酸等温扩增及CRISPR分子诊断检测技术
2 新型分子诊断技术在重大疾病精准诊断中的应用研究
招收要求：
课题组招收博士研究生1人（化学）、硕士研究生3-4人（化学、化学工程）、博士后2人。
具备分析化学、仪器分析的知识，具有生物化学、分子生物学、生物医学工程、药学等背景更优
有责任感、较强的自我学习驱动力、勤奋、对交叉学科具有热情、有团队合作精神。
2025年
7.Yan Zhu,Junwei Lai,Xinyao Yang,Shuqing Wang,Dayong Gu,Yan Huang*,Yizhen Liu*,Conghui Liu*.CRISPR/Cas13a-driven lateral flow assay for preamplification-free and ultrasensitive miRNA-21 detection.Biosensors and Bioelectronics.2025,288,117850.
6.Songkuan Zhuang,Xiaojun Huang,Muyan Diao,Ruiling Dong,Yueyu Dong,Jun Liu*,Yizhen Liu*,CONVERT: Dynamic crRNA Reconfiguration for Universal One-Pot CRISPR/Cas12a-Based Nucleic Acid Detection.Analytical Chemistry.DOI:10.1021/acs.analchem.5c03577.[link]
5.Songkuan Zhuang,Botao Bai,Yizhen Liu*,CRISPR-based SNP detection technologies advance from classical methods to cutting-edge innovations.Chemical communications.2025,Advance Article.DOI:https://doi.org/10.1039/D5CC03655K.[link]
4.Songkuan Zhuang,Yueyu Dong,Xiaojun Huang,Tonggong Liu,Dayong Gu*,Yizhen Liu*.A universal Cas12a activity regulation strategy via photocleavable crRNA 3’-terminal additives enables one-pot CRISPR detection of arboviruses.Chemical Engineering Journal.2025,521,166699.[link]
3.Siyuan Luo,Yong Chen,Zongnan Li,Xueji Zhang,Yizhen Liu*.Single-tube Lambda exonuclease-mediated LbuCas13a detect of ssDNA for single-nucleotide polymorphisms genotyping.Biosensors and Bioelectronics.2025,288,117760.[link]
2.Jialing Zhong, Yong Chen, Yueyu Dong, Chuanghao Guo, and Yizhen Liu*.SPARC: An Orthogonal Cas12a/Cas13a Dual-Channel CRISPR Platform for Reliable SNV Identification and Mutation Confirmation.Anal. Chem.2025,97,27,14629-14636.[link]
1.Xiaolong Wu#, Siyuan Luo#, Chuanghao Guo, Yi Zhao, Jialing Zhong, Ronghuan Hu, Xinyao Yang, Conghui Liu, Qianling Zhang, Songkuan Zhuang, Yong Chen*, Yizhen Liu * , and Xueji Zhang*.LbuCas13a directlytargets DNA and elicits strong trans-cleavage activity. Nature Biomedical Engineering. DOI:https://doi.org/10.1038/s41551-025-01424-6.[link]
2024年
3.Jialing Zhong, Xiaolong Wu, Chuanghao Guo, Conghui Liu, Qianling Zhang, Yong Chen*,and Yizhen Liu*. A Single-Tube, Single-Enzyme Clustered Regularly Interspaced Short Palindromic Repeats System (UNISON) with Internal Controls for Accurate Nucleic Acid Detection.Anal. Chem.2024,96,49,19348-19353.[link]
2.Qiang Fu, Jiaheng Li, Stephan Handschuh-Wang, Xuechang Zhou, Yizhen Liu*. Synergistic effect of NiFe2O4 and MWCNTs for ppb-level acetone detection at 150oC. Sensors and Actuators B: Chemical. 2024, 136948, 0925-4005.
1.Ronghuan Hu, Chuanghao Guo, Conghui Liu, Qianling Zhang, Xueji Zhang, Yong Chen*, and Yizhen Liu*. From Lab to Home: Ultrasensitive Rapid Detection of SARS-CoV-2 with a Cascade CRISPR/Cas13a-Cas12a System Based Lateral Flow Assay. Anal. Chem. 2024, 96, 35
